Regional iron distribution and soluble ferroprotein profiles in the healthy human brain

Erin J McAllum; Dominic J Hare; Irene Volitakis; Catriona A McLean; Ashley I Bush; David I Finkelstein; Blaine R Roberts

Journal article

Regional iron distribution and soluble ferroprotein profiles in the healthy human brain

Erin J McAllum, Dominic J Hare, Irene Volitakis, Catriona A McLean, Ashley I Bush, David I Finkelstein, Blaine R Roberts

Progress in Neurobiology | Elsevier | Published : 2020

DOI: 10.1016/j.pneurobio.2019.101744

Abstract

Iron is essential for brain development and health where its redox properties are used for a number of neurological processes. However, iron is also a major driver of oxidative stress if not properly controlled. Brain iron distribution is highly compartmentalised and regulated by a number of proteins and small biomolecules. Here, we examine heterogeneity in regional iron levels in 10 anatomical structures from seven post-mortem human brains with no apparent neuropathology. Putamen contained the highest levels, and most case-to-case variability, of iron compared with the other regions examined. Partitioning of iron between cytosolic and membrane-bound iron was generally consistent in each reg..

View full abstract

University of Melbourne Researchers

Dominic Hare Author

Catriona McLean Author

Ashley Bush Author

David Finkelstein Author

Related Projects (2)

Iron, ferroptosis and the biology of ageing

This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing b..

TRACING IRON FROM NEURODEVELOPMENT TO NEURODEGENERATION IN PARKINSON'S DEISEASE

Excessive brain iron can cause neurodegeneration in Parkinson's disease (PD). This project will examine a link between early-life iron expos..

Grants

Awarded by NHMRC-ARC Dementia Research Development Fellowship

Awarded by NHMRC Career Development Fellowship - Industry

Awarded by NHMRC

Awarded by ARC

Funding Acknowledgements

Funding for this project was provided by the National Health & Medical Research Council and Australian Research Council. EJM is supported by an NHMRC-ARC Dementia Research Development Fellowship (GNT1105791); DJH is the recipient of an NHMRC Career Development Fellowship - Industry (GNT1122981) in partnership with Agilent Technologies Australia. AIB is an NHMRC Senior Principal Research Fellow (GNT 1103703), and DJH and AIB are supported by an ARC Discovery Project (DP180101248). BRR receives an NHMRC Boosting Dementia Research Leadership Fellowship (GNT1138673) and NHMRC project grant (GNT1164692). This work was also supported by an ARC Linkage Grant (LP14010095) to DJH and BRR, also supported by Agilent Technologies. The Florey Institute of Neuroscience and Mental Health acknowledge the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant.